Immunoserologic Detection and Diagnostic Relevance of Cross-Reactive Autoantibodies in Coronavirus Disease 2019 Patients.
Identifieur interne : 000513 ( Main/Exploration ); précédent : 000512; suivant : 000514Immunoserologic Detection and Diagnostic Relevance of Cross-Reactive Autoantibodies in Coronavirus Disease 2019 Patients.
Auteurs : María Teresa Schiaffino [Espagne] ; Marisa Di Natale [Espagne] ; Elena García-Martínez [Espagne] ; Joaquín Navarro [Espagne] ; José Luis Mu Oz-Blanco [Espagne] ; Pablo Demelo-Rodríguez [Espagne] ; Paloma Sánchez-Mateos [Espagne]Source :
- The Journal of infectious diseases [ 1537-6613 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Animaux (MeSH), Autoanticorps (sang), Betacoronavirus (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Ferritines (sang), Humains (MeSH), Infections à coronavirus (complications), Infections à coronavirus (immunologie), Infections à coronavirus (sang), Jeune adulte (MeSH), Maladies du système nerveux (immunologie), Maladies du système nerveux (virologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (complications), Pneumopathie virale (immunologie), Pneumopathie virale (sang), Rats (MeSH), Réactions croisées (immunologie), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Séroconversion (MeSH), Technique d'immunofluorescence indirecte (MeSH), Tests sérologiques (MeSH), Thrombose (immunologie), Thrombose (virologie), Études cas-témoins (MeSH).
- MESH :
- immunologie : Infections à coronavirus, Maladies du système nerveux, Pneumopathie virale, Réactions croisées, Thrombose.
- sang : Autoanticorps, Ferritines, Infections à coronavirus, Pneumopathie virale.
- virologie : Maladies du système nerveux, Thrombose.
- Adulte, Adulte d'âge moyen, Animaux, Betacoronavirus, Facteurs âges, Femelle, Humains, Jeune adulte, Mâle, Pandémies, Rats, Sujet âgé, Sujet âgé de 80 ans ou plus, Séroconversion, Technique d'immunofluorescence indirecte, Tests sérologiques, Études cas-témoins.
English descriptors
- KwdEn :
- Adult (MeSH), Age Factors (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Animals (MeSH), Autoantibodies (blood), Betacoronavirus (MeSH), Case-Control Studies (MeSH), Coronavirus Infections (blood), Coronavirus Infections (complications), Coronavirus Infections (immunology), Cross Reactions (immunology), Female (MeSH), Ferritins (blood), Fluorescent Antibody Technique, Indirect (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Nervous System Diseases (immunology), Nervous System Diseases (virology), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (complications), Pneumonia, Viral (immunology), Rats (MeSH), Seroconversion (MeSH), Serologic Tests (MeSH), Thrombosis (immunology), Thrombosis (virology), Young Adult (MeSH).
- MESH :
- chemical , blood : Autoantibodies, Ferritins.
- blood : Coronavirus Infections, Pneumonia, Viral.
- complications : Coronavirus Infections, Pneumonia, Viral.
- immunology : Coronavirus Infections, Cross Reactions, Nervous System Diseases, Pneumonia, Viral, Thrombosis.
- virology : Nervous System Diseases, Thrombosis.
- Adult, Age Factors, Aged, Aged, 80 and over, Animals, Betacoronavirus, Case-Control Studies, Female, Fluorescent Antibody Technique, Indirect, Humans, Male, Middle Aged, Pandemics, Rats, Seroconversion, Serologic Tests, Young Adult.
Abstract
BACKGROUND
During the coronavirus disease 2019 (COVID-19) pandemic, we detected a new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients.
METHODS
The IF pattern was composed of liver and gastric mucosa staining on rat kidney/liver/stomach sections.
RESULTS
We describe 12 patients positive for the cross-reactive antibody, compared with a negative group of 43 hospitalized COVID-19 patients, finding association with either neurologic or thrombotic complications. In sequential pre- and post-COVID-19 serum samples, we confirmed autoAb seroconversion.
CONCLUSIONS
Our data indicate that autoAb screening in COVID-19 patients may be easily performed by IF and alert for autoreactive-mediated complications such as thrombotic or neurologic events.
DOI: 10.1093/infdis/jiaa485
PubMed: 32738141
PubMed Central: PMC7454719
Affiliations:
Links toward previous steps (curation, corpus...)
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uniqKey="Schiaffino M" first="María Teresa" last="Schiaffino">María Teresa Schiaffino</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Di Natale, Marisa" sort="Di Natale, Marisa" uniqKey="Di Natale M" first="Marisa" last="Di Natale">Marisa Di Natale</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Garcia Martinez, Elena" sort="Garcia Martinez, Elena" uniqKey="Garcia Martinez E" first="Elena" last="García-Martínez">Elena García-Martínez</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Navarro, Joaquin" sort="Navarro, Joaquin" uniqKey="Navarro J" first="Joaquín" last="Navarro">Joaquín Navarro</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Mu Oz Blanco, Jose Luis" sort="Mu Oz Blanco, Jose Luis" uniqKey="Mu Oz Blanco J" first="José Luis" last="Mu Oz-Blanco">José Luis Mu Oz-Blanco</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Demelo Rodriguez, Pablo" sort="Demelo Rodriguez, Pablo" uniqKey="Demelo Rodriguez P" first="Pablo" last="Demelo-Rodríguez">Pablo Demelo-Rodríguez</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Medicina Interna, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Medicina Interna, Hospital General Universitario Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Sanchez Mateos, Paloma" sort="Sanchez Mateos, Paloma" uniqKey="Sanchez Mateos P" first="Paloma" last="Sánchez-Mateos">Paloma Sánchez-Mateos</name><affiliation wicri:level="3"><nlm:affiliation>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Age Factors (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Animals (MeSH)</term><term>Autoantibodies (blood)</term><term>Betacoronavirus (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Coronavirus Infections (blood)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (immunology)</term><term>Cross Reactions (immunology)</term><term>Female (MeSH)</term><term>Ferritins (blood)</term><term>Fluorescent Antibody Technique, Indirect (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Nervous System Diseases (immunology)</term><term>Nervous System Diseases (virology)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (blood)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (immunology)</term><term>Rats (MeSH)</term><term>Seroconversion (MeSH)</term><term>Serologic Tests (MeSH)</term><term>Thrombosis (immunology)</term><term>Thrombosis (virology)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Animaux (MeSH)</term><term>Autoanticorps (sang)</term><term>Betacoronavirus (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Ferritines (sang)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (complications)</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (sang)</term><term>Jeune adulte (MeSH)</term><term>Maladies du système nerveux (immunologie)</term><term>Maladies du système nerveux (virologie)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (complications)</term><term>Pneumopathie virale (immunologie)</term><term>Pneumopathie virale (sang)</term><term>Rats (MeSH)</term><term>Réactions croisées (immunologie)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Séroconversion (MeSH)</term><term>Technique d'immunofluorescence indirecte (MeSH)</term><term>Tests sérologiques (MeSH)</term><term>Thrombose (immunologie)</term><term>Thrombose (virologie)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Autoantibodies</term><term>Ferritins</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladies du système nerveux</term><term>Pneumopathie virale</term><term>Réactions croisées</term><term>Thrombose</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Cross Reactions</term><term>Nervous System Diseases</term><term>Pneumonia, Viral</term><term>Thrombosis</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Autoanticorps</term><term>Ferritines</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies du système nerveux</term><term>Thrombose</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Nervous System Diseases</term><term>Thrombosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Betacoronavirus</term><term>Case-Control Studies</term><term>Female</term><term>Fluorescent Antibody Technique, Indirect</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Rats</term><term>Seroconversion</term><term>Serologic Tests</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Betacoronavirus</term><term>Facteurs âges</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Pandémies</term><term>Rats</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Séroconversion</term><term>Technique d'immunofluorescence indirecte</term><term>Tests sérologiques</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>During the coronavirus disease 2019 (COVID-19) pandemic, we detected a new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>The IF pattern was composed of liver and gastric mucosa staining on rat kidney/liver/stomach sections.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We describe 12 patients positive for the cross-reactive antibody, compared with a negative group of 43 hospitalized COVID-19 patients, finding association with either neurologic or thrombotic complications. In sequential pre- and post-COVID-19 serum samples, we confirmed autoAb seroconversion.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Our data indicate that autoAb screening in COVID-19 patients may be easily performed by IF and alert for autoreactive-mediated complications such as thrombotic or neurologic events.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32738141</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>13</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6613</ISSN><JournalIssue CitedMedium="Internet"><Volume>222</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>10</Month><Day>01</Day></PubDate></JournalIssue><Title>The Journal of infectious diseases</Title><ISOAbbreviation>J Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Immunoserologic Detection and Diagnostic Relevance of Cross-Reactive Autoantibodies in Coronavirus Disease 2019 Patients.</ArticleTitle><Pagination><MedlinePgn>1439-1443</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiaa485</ELocationID><Abstract><AbstractText Label="BACKGROUND">During the coronavirus disease 2019 (COVID-19) pandemic, we detected a new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients.</AbstractText><AbstractText Label="METHODS">The IF pattern was composed of liver and gastric mucosa staining on rat kidney/liver/stomach sections.</AbstractText><AbstractText Label="RESULTS">We describe 12 patients positive for the cross-reactive antibody, compared with a negative group of 43 hospitalized COVID-19 patients, finding association with either neurologic or thrombotic complications. In sequential pre- and post-COVID-19 serum samples, we confirmed autoAb seroconversion.</AbstractText><AbstractText Label="CONCLUSIONS">Our data indicate that autoAb screening in COVID-19 patients may be easily performed by IF and alert for autoreactive-mediated complications such as thrombotic or neurologic events.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schiaffino</LastName><ForeName>María Teresa</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Natale</LastName><ForeName>Marisa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-Martínez</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Navarro</LastName><ForeName>Joaquín</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muñoz-Blanco</LastName><ForeName>José Luis</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demelo-Rodríguez</LastName><ForeName>Pablo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Servicio de Medicina Interna, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sánchez-Mateos</LastName><ForeName>Paloma</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Infect Dis</MedlineTA><NlmUniqueID>0413675</NlmUniqueID><ISSNLinking>0022-1899</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001323">Autoantibodies</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-73-2</RegistryNumber><NameOfSubstance UI="D005293">Ferritins</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001323" MajorTopicYN="N">Autoantibodies</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" 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MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009422" MajorTopicYN="N">Nervous System Diseases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000069078" MajorTopicYN="N">Seroconversion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012698" MajorTopicYN="N">Serologic Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013927" MajorTopicYN="N">Thrombosis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">autoantibody</Keyword><Keyword MajorTopicYN="Y">autoimmunity</Keyword><Keyword MajorTopicYN="Y">immunofluorescence</Keyword><Keyword MajorTopicYN="Y">molecular mimicry</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32738141</ArticleId><ArticleId IdType="pii">5879761</ArticleId><ArticleId IdType="doi">10.1093/infdis/jiaa485</ArticleId><ArticleId IdType="pmc">PMC7454719</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Schiaffino, Maria Teresa" sort="Schiaffino, Maria Teresa" uniqKey="Schiaffino M" first="María Teresa" last="Schiaffino">María Teresa Schiaffino</name></region><name sortKey="Demelo Rodriguez, Pablo" sort="Demelo Rodriguez, Pablo" uniqKey="Demelo Rodriguez P" first="Pablo" last="Demelo-Rodríguez">Pablo Demelo-Rodríguez</name><name sortKey="Di Natale, Marisa" sort="Di Natale, Marisa" uniqKey="Di Natale M" first="Marisa" last="Di Natale">Marisa Di Natale</name><name sortKey="Garcia Martinez, Elena" sort="Garcia Martinez, Elena" uniqKey="Garcia Martinez E" first="Elena" last="García-Martínez">Elena García-Martínez</name><name sortKey="Mu Oz Blanco, Jose Luis" sort="Mu Oz Blanco, Jose Luis" uniqKey="Mu Oz Blanco J" first="José Luis" last="Mu Oz-Blanco">José Luis Mu Oz-Blanco</name><name sortKey="Navarro, Joaquin" sort="Navarro, Joaquin" uniqKey="Navarro J" first="Joaquín" last="Navarro">Joaquín Navarro</name><name sortKey="Sanchez Mateos, Paloma" sort="Sanchez Mateos, Paloma" uniqKey="Sanchez Mateos P" first="Paloma" last="Sánchez-Mateos">Paloma Sánchez-Mateos</name><name sortKey="Sanchez Mateos, Paloma" sort="Sanchez Mateos, Paloma" uniqKey="Sanchez Mateos P" first="Paloma" last="Sánchez-Mateos">Paloma Sánchez-Mateos</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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